Entrectinib 100mg Capsules are a breakthrough treatment option designed to target specific genetic alterations found in various solid tumors. As an oral tyrosine kinase inhibitor (TKI), entrectinib is particularly effective for patients with NTRK gene fusion-positive cancers, ROS1-positive non-small cell lung cancer (NSCLC), and other advanced solid tumors harboring actionable targets.

What is Entrectinib?

Entrectinib is an innovative, targeted therapy that works by inhibiting key proteins involved in tumor growth and proliferation. It specifically targets:

• NTRK gene fusions: Present in a wide variety of solid tumors.
• ROS1 rearrangements: Common in certain lung cancers.
• ALK alterations: Though less common, some tumors may also benefit from its action on ALK.

This precision medicine approach allows entrectinib to interfere with the abnormal signaling pathways that drive cancer progression, offering a personalized treatment strategy for patients with these genetic mutations.

Entrectinib acts as a potent inhibitor of multiple tyrosine kinases:

• Inhibition of TRK proteins (encoded by NTRK genes): Blocks the signaling that leads to uncontrolled cell growth.
• Inhibition of ROS1: Interferes with pathways crucial for the survival of certain lung cancer cells.
• Inhibition of ALK (anaplastic lymphoma kinase): Further expands its utility in treating tumors with diverse genetic backgrounds.

By targeting these kinases, entrectinib disrupts the growth and survival mechanisms of cancer cells while sparing most normal cells, which can result in a better tolerability profile compared to traditional chemotherapies.

Common Side Effects

Patients taking entrectinib may experience:

• Fatigue
• Dizziness
• Nausea
• Dysgeusia (altered taste)
• Constipation

Important Safety Information

• Liver Function: Monitoring of liver enzymes is recommended due to potential hepatotoxicity.
• Neurological Effects: Some patients may experience neurological symptoms, which require prompt evaluation by a healthcare provider.
• Drug Interactions: Patients should inform their doctor about all medications they are taking, as entrectinib may interact with other treatments.

Patient Considerations

• Genetic Testing: Before starting therapy, patients should undergo genetic testing to confirm the presence of NTRK fusions, ROS1 rearrangements, or ALK alterations.
• Tailored Therapy: Treatment with entrectinib is highly individualized, and its use should be part of a comprehensive cancer care plan developed by a multidisciplinary team.

Disclaimer

RxLane provides information for educational purposes only. All trademarks, brands, and service marks are the property of their respective owners. RxLane does not offer medical advice. Please consult your doctor for appropriate diagnosis and treatment. This content is intended for wholesalers, doctors, hospitals, clinics, pharmacies, and medical institutions.