Ponatinib Tablets are an essential targeted therapy used in the treatment of specific types of leukemia, including chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Available in 15mg and 45mg strengths, Ponatinib works as a tyrosine kinase inhibitor (TKI), blocking the proteins responsible for cancer cell growth.

What is Ponatinib 15mg/45mg Used For?

• Chronic Myeloid Leukemia (CML) – Including cases resistant to other TKIs
• Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL)
• Specifically effective against CML patients with the T315I mutation, which is resistant to most other TKIs.

Ponatinib blocks BCR-ABL1 kinase activity, a critical driver of leukemia cell proliferation. By inhibiting this abnormal protein, Ponatinib helps stop cancer cell growth, inducing remission in some cases.

Indications

• Chronic Myeloid Leukemia (CML): Especially useful in patients who are resistant to or intolerant of other TKIs.
• Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL): Used in cases where traditional treatment options have not been effective.

Mechanism of Action

Ponatinib works by inhibiting the activity of multiple tyrosine kinases, particularly the BCR-ABL1 kinase, thereby stopping the growth of malignant cells. Its efficacy in cases with the T315I mutation makes it a crucial option for patients who have exhausted other treatment alternatives.

Dosage Forms & Strengths

• 15mg Tablets: Often used for dose adjustments or maintenance therapy.
• 45mg Tablets: Commonly prescribed as the standard starting dose for many patients before any dose modification based on response or adverse events.

Safety & Side Effects

Like all medications, Ponatinib may cause side effects. Common adverse reactions include:

• Hypertension
• Abdominal pain
• Skin rash
• Headaches
• Elevated liver enzymes

Important: Patients should be monitored for cardiovascular events and other serious complications. Always discuss potential side effects and drug interactions with your healthcare provider before starting treatment.

Contraindications & Interactions

• Contraindications: Ponatinib is contraindicated in patients with known hypersensitivity to the drug.
• Drug Interactions: Inform your doctor of any other medications you are taking, as Ponatinib may interact with certain drugs, particularly those affecting liver enzymes.

Disclaimer

RxLane provides information for educational purposes only. All trademarks, brands, and service marks are the property of their respective owners. RxLane does not offer medical advice. Please consult your doctor for appropriate diagnosis and treatment. This content is intended for wholesalers, doctors, hospitals, clinics, pharmacies, and medical institutions.