Natco Everolimus Tablets Specification:

  
RAPACT

RAPACT is an immunosuppressant. It works by blocking the action of certain blood cells in the immune system that may cause the body to reject the transplanted organ.

MEDICINAL USES

RAPACT is used with other medications (such as cyclosporine) to prevent rejection of a kidney transplant. Everolimus is also used with other medications (such as tacrolimus) to prevent rejection of a liver transplant.

RAPACT COMMON SIDE EFFECTS :

Constipation, headache, nausea, and sores in the mouth/throat may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Tell your doctor right away if you have any serious side effects, including: swelling hands/ankles/feet, wound problems (such as infection, slow wound healing, opening of wound), decreased sexual ability (in men), chest pain/pressure, shortness of breath, unusual bruising/bleeding.

Everolimus may cause your cholesterol/triglycerides or blood sugar to increase.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

SAFETY INFORMATION (Precautions) :

·         Before using this medication, tell your doctor or pharmacist your medical history, especially of: previous cancer treatments (including radiation therapy to the chest), heart disease, high blood pressure, previous severe reaction to monoclonal antibody treatment.

·         Perjeta can make you more likely to get infections or may worsen any current infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

·         Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

·         Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using Pertuzumab. This medication may harm an unborn baby.

·         It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding is not recommended while using this drug or for 7 months after the last dose. Consult your doctor before breast-feeding.

STORAGE OF RAPACT :

Store at room temperature of 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Protect from light; protect from moisture.

RAPACT INTERACTIONS :

Some products that may interact with this drug include: other drugs that weaken the immune system/increase the risk of infection (such as natalizumab, rituximab), ACE inhibitors (such as captopril, lisinopril).

Other medications can affect the removal of everolimus from your body, which may affect how everolimus works. Examples include :

    azole antifungals (such as itraconazole, ketoconazole),
    boceprevir,
    cobicistat,
    macrolide antibiotics (such as clarithromycin, erythromycin),
    HIV protease inhibitors (such as atazanavir, ritonavir),
    rifamycins (such as rifabutin, rifampin),
    St. John's wort, telaprevir, telithromycin, among others.

This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.