Tivozanib 0.89mg/1.34mg Capsules – Advanced Targeted Therapy for Cancer Treatment

Tivozanib is an innovative oral targeted therapy designed to inhibit tumor angiogenesis by selectively blocking vascular endothelial growth factor receptors (VEGFRs). Available in 0.89mg and 1.34mg capsule strengths, Tivozanib offers oncologists a flexible dosing option for patients with advanced cancers, most notably in the treatment of renal cell carcinoma (RCC).

What is Tivozanib?

Tivozanib belongs to a class of medications known as tyrosine kinase inhibitors (TKIs). It is engineered to selectively target and inhibit VEGFRs, which are critical for the formation of new blood vessels (angiogenesis). By reducing the blood supply that tumors rely on, Tivozanib can effectively slow tumor growth and metastasis.

Tivozanib exerts its therapeutic effect by:

• Inhibiting VEGFRs: It blocks VEGFR-1, VEGFR-2, and VEGFR-3, key drivers of angiogenesis.
• Reducing Tumor Blood Supply: By impairing the development of new blood vessels, the drug starves the tumor of oxygen and nutrients.
• Stabilizing Disease Progression: This targeted approach can help control tumor growth and potentially improve patient outcomes in advanced cancer settings.

Tivozanib is primarily used for the treatment of:

• Advanced Renal Cell Carcinoma (RCC): Especially in patients who have relapsed or are refractory to other treatments.
• Other Solid Tumors: Research is ongoing to evaluate the efficacy of Tivozanib in additional cancer types, making it a promising candidate for broader oncological applications.

Available Strengths for Tivozanib Capsules

• 0.89mg Capsules: May be used in dose-adjustment protocols or specific clinical situations requiring a lower starting dose.
• 1.34mg Capsules: Commonly used as the standard dosing strength for achieving optimal therapeutic effect.

Administration Guidelines

• Oral Intake: Tivozanib is taken by mouth, allowing for convenient outpatient management.
• Dosing Schedule: The specific dosing regimen should be determined by an oncologist based on the patient’s overall health, disease state, and prior treatments. Consistency in dosing times is important for maintaining steady drug levels in the body.

Side Effects of Tivozanib Capsules

While Tivozanib is generally well-tolerated, patients may experience side effects that require monitoring and management. Common side effects include:

• Hypertension: Regular blood pressure monitoring is recommended.
• Hand-Foot Syndrome: Skin reactions on the palms and soles may occur.
• Fatigue: Patients might experience tiredness, especially during the initial phases of treatment.
• Gastrointestinal Disturbances: Such as diarrhea or nausea.

Important Safety Considerations

• Monitoring: Frequent assessments of blood pressure, liver function, and overall patient status are crucial.
• Drug Interactions: Patients should inform their healthcare provider about all medications they are taking, as Tivozanib may interact with other treatments.
• Patient Education: It is essential that patients are aware of the potential side effects and the importance of adhering to follow-up schedules.

Frequently Asked Questions (FAQs) for Tivozanib Capsules

1. What type of cancer is Tivozanib used for?

Answer: Tivozanib is primarily used for treating advanced renal cell carcinoma (RCC), particularly in patients who have not responded to previous therapies. Ongoing studies are also exploring its use in other solid tumors.

2. How does Tivozanib work?

Answer: Tivozanib works by selectively inhibiting VEGFRs, which reduces tumor blood vessel formation, thereby starving the tumor of nutrients and slowing its growth.

3. What are the available capsule strengths?

Answer: Tivozanib is available in two strengths – 0.89mg and 1.34mg capsules. The appropriate strength and dosing schedule will be determined by the treating oncologist.

4. What side effects should I expect?

Answer: Common side effects include hypertension, hand-foot syndrome, fatigue, and gastrointestinal disturbances. Regular monitoring by your healthcare provider will help manage these side effects effectively.

5. Can Tivozanib be taken with food?

Answer: Tivozanib is taken orally, and your doctor will advise on whether to take it with or without food based on your specific treatment plan.

Disclaimer

RxLane provides information for educational purposes only. All trademarks, brands, and service marks are the property of their respective owners. RxLane does not offer medical advice. Please consult your doctor for appropriate diagnosis and treatment. This content is intended for wholesalers, doctors, hospitals, clinics, pharmacies, and medical institutions.