ABOUT
MEGVAL MELPHALAN INJECTION:

MEGVAL for Injection is provided as a sterile, nonpyrogenic,
solidify dried powder. Each single-utilize vial contains melphalan
hydrochloride equal to 50 mg melphalan and 20 mg povidone. MEGVAL for Injection
is reconstituted utilizing the sterile diluent gave. Every vial of sterile
diluent has sodium citrate 0.2 g, propylene glycol 6.0 ml, ethanol (96%) 0.52 ml,
and Water for Injection to an aggregate of 10 ml. It is directed by veins.

 

MEDICINE
USES:

Melphalan is a bifunctional alkylating agent that is active
against selected human neoplastic diseases. Melphalan is utilized in the
treatment of cancer chemotherapeutic agents. In the chemotherapy it kills the
cancer cells and blocks their supplements to develop and spread their growth.
It is also used in:

Multiple myeloma – a cancer that develops from cells in the bone
marrow called plasma cells. Plasma cells help to fight infection and disease by
producing antibodies

Advanced cancer of the ovaries: Ovarian cancer cells divide and multiply in an
unregulated way.

Childhood neuroblastoma – cancer of the nervous system to a baby in
childhood.

Malignant melanoma – skin cancer.

Soft tissue sarcoma – cancer of the muscle, fat, fibrous tissue, blood
vessels, or other supporting tissue of the body.

 

 

MELPHALAN
COMMON SIDE EFFECTS:

Call your doctor for medical advice about side effects.

·        
Missed
menstrual periods; weakness; temporary hair loss.

·        
Bone
marrow suppression: Sudden weakness or ill feeling, fever, chills, pale skin,
easy bruising or bleeding, red or pink urine, painful mouth sores, cough,
trouble breathing, feeling light-headed, rapid heart rate;

·        
Inflammation
of your blood vessels: numbness or tingling, red skin rash, unusual lumps or
masses, fever, weight loss, muscle or joint pain, tired feeling, unusual
bleeding;

·        
Liver
problems: nausea, upper stomach pain, itching, loss of appetite, dark urine,
clay-colored stools, jaundice.

 

MEGVAL
MELPHALAN INJECTION PRECAUTIONS:

·        
Megval
may lower the ability of your body to fight infection. Avoid contact with
people who have colds or infections. Tell your doctor if you notice signs of
infection like fever, sore throat, rash, or chills.

·        
Do not
receive a live vaccine, while you are taking Melphalan. Talk with your doctor
before you receive any vaccine.

·        
Use of
Megval may increase your risk of developing another type of cancer. The risk
may be greater if you use higher doses of this medicine or if you use it for a
longer period of time. Discuss any questions or concerns with your doctor.

·        
Megval
may affect the ovaries. This may cause irregular or absent menstrual periods
and decreased fertility in some women. Discuss any questions or concerns with
your doctor.

·        
Megval
may affect the testicles and cause decreased fertility in some men. This may be
permanent in some patients. Discuss any questions or concerns with your doctor.

·        
PREGNANCY
and BREAST-FEEDING: Melphalan has been shown to cause harm to the fetus. Avoid
becoming pregnant while taking it. If you think you may be pregnant, contact
your doctor.

·        
You will
need to discuss the benefits and risks of using this medicine while you are
pregnant. It is unknown if Generic Melphalan is found in breast milk. Do not breast-feed
while taking it.

MEDICATION
STORAGE REQUIREMENTS:

Store at 20° to 25°C (68° to 77°F).

 

DRUG
INTERACTIONS:

Tell your health care provider if you are taking any other
medicines, especially any of the following:

Cisplatin because the risk of Melphalan’s side effects may be
increased.

Carmustine (BCNU), cyclosporine, or nalidixic acid because
serious lung, kidney, or bowel problems may occur.

Palifermin because if mouth or tongue sores develop, they may
be more severe or last longer.

Medicine Specifications:

Brand Name: Metaspray
Contents: Mometasone furoate
Strength: 50 mcg x 1 puff x 100md
Form: Nasal Spray
Manufactured By: Cipla Limited

MINIRIN 0.2 MG TABLETS

Minirin 0.2 mg Tablet has the same structure
as that of the natural hormone vasopressin. Vasopressin lowers the amount of
urine and bleeding by constricting (narrowing) the blood vessels which, in
turn, prevents the loss of water from the body.

USE OF MINIRIN  0.2 MG DESMOPRESSIN TABLETS

Minirin
0.2 mg Tablet is used in the treatment of diabetes insipidus and bed-wetting.

Minirin 0.2 mg Tablet is used for the control,
treatment and prevention of conditions such as bedwetting, diabetes insipidus, and Von
willebrand’s disease. It works by limiting the amount of water eliminated
through urination.

Minirin
tablets 0.2 mg are used to treat several conditions characterised by over
production of urine or uncontrolled release of urine.  Normally the amount
of urine produced in the kidneys is controlled by vasopressin (arginine
vasopressin or AVP), also known as antidiuretic hormone (ADH), a hormone
produced in the hypothalamus of the brain, stored in the pituitary gland and
released in response to dehydration, such as through perspiration or
insufficient water intake.  AVP acts directly on the kidney tubules to
cause reabsorption of water as the urine passes through.

SIDE-EFFECTS OF DESMOPRESSIN 0.2 MG
MINIRIN TABLETS

Possible side
effects of Minirin 0.2 mg Tablet include nausea, lightheadedness, headache,
belly pain, and abdominal cramps. If you experience side effects other than the
ones listed above, you need to contact your doctor for immediate medical
assistance.

In addition to its intended effect, Minirin 0.2 mg
Tablet may cause some unwanted effects too. In such cases, you must seek
medical attention immediately. This is not an exhaustive list of side effects.
Please inform your doctor if you experience any adverse reaction to the
medication.

MINIRIN TABLETS – DRUGS INTERACTIONS: 

 Do not use Minirin
0.2 mg Tablet if you are allergic to any of the ingredients present in it.
Before using Minirin 0.2 mg Tablet tell your doctor if you are using any
prescription drugs, non-prescription drugs, or other herbal and dietary pills
and supplements, if you are pregnant and/or breastfeeding, if you have abnormal
sodium/potassium blood levels, if you suffer from congestive heart
failure, if you have coronary artery disease, if you have a history
of migraineheadaches, if you have abnormally high/low blood pressure, or
if you have any upcoming surgeries. Also let your doctor know your history of
medical problems, pre-existing diseases and current health conditions. Extreme
caution should be taken while administering this medication to the elderly.

Whenever you take more than one medicine, or mix it
with certain foods or beverages, you’re at risk of a drug interaction.

MINIRIN TABLETS – DRUGS PRECAUTIONS:

Consult your doctor if you are suffering from
any of the following conditions: kidney disease, heart diseases such as
coronary artery disease, congestive heart failure, high/low blood pressure,
abnormal levels of sodium/potassium in blood (electrolyte imbalance), cystic
fibrosis or any psychological condition causing unusual thirst; asthma,
epilepsy (fits) or migraine headache.

Restricting the intake of water or other fluids
is very important while taking desmopressin. Drinking excess water during
desmopressin therapy may cause life-threatening electrolyte imbalance, and may
also cause fits. Follow your doctor’s instructions carefully about fluid intake.

Tell your
doctor if you are pregnant or are planning to become pregnant or are
breast-feeding.
Restrict consumption of alcohol as
it may worsen the side effects.
Low doses of desmopressin should be
taken without food for better effect.